I have chronic insomnia, and both St. John's Wort and Tryptophayn HTP something were recommended to me as sleep aids. They both made me extremely irritable, which said to me that my problem is not serotonin related.
SJW made me weirdly buzzy the first time I took it (when my depression was probably situational rather than anything else). I can easily see how the sensation would translate into irritability for a lot of people - it made me really uncomfortable, and it was unpleasantly close to the sensation I get when PMSing or going through other hormonal changes, which really does make me irritable.
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